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通过对冻干低ｐＨ静注免疫球蛋白成品的检测和临床使用观察，发现对献血者进行抗－ＨＣＶ抗体筛选，可使成品抗－ＨＣＶ阳性率大幅度降低。由于筛选方法的限制和ＨＣＶ感染后空窗期的存在，合并后的原料血浆污染ＨＣＶ在所难免；冻干低ｐＨ静注免疫球蛋白成品无论其抗－ＨＣＶ是阴性还是阳性，ＰＣＲ检测ＨＣＶ－ＲＮＡ均为阴性的实验结果提示制备工艺过程可以去除ＨＣＶ。临床初步观察和回顾性调查中均未发现ＨＣＶ传播的迹象。
Through the freeze-dried low pH intravenous immunoglobulin product testing and clinical observation, we found that anti-HCV antibody screening for blood donors, finished products can significantly reduce the positive rate of anti-HCV. Due to the restriction of the screening method and the presence of empty windows after HCV infection, it is unavoidable that the pooled raw plasma-contaminated HCV is ineffective; freeze-dried low pH intravenous immunoglobulin products whether negative or positive for anti-HCV, The RNA negative results suggest that the preparation process can remove HCV. No evidence of HCV transmission was found in both clinical and retrospective studies.