卤泛曲林是一种对多药抗性恶性疟有效的药物。少数复燃病例被归因于药物吸收不良。本文作者用微粒型卤泛曲林治疗28例22—54岁无免疫力且无并发症的恶性疟病人,以观察其疗效、耐受性及原药和其N-去丁基代谢物的药物动力学。卤泛曲林的疗效用退热时间和原虫清除时间来评价。确定疟原虫对卤泛曲林的抗性需符合以下3点:1) Bromofloxacin is a drug that is effective against multidrug-resistant falciparum malaria. A small number of relapse cases are attributable to poor malabsorption. In this study, 28 patients with 22-54 years of immunocompromised falciparum malaria were treated with the microparticulate halibutramine to observe their efficacy and tolerability, as well as their drugs and their N-butyl metabolites dynamics. The efficacy of halibutramine is evaluated by the time of pyrexia and protozoal clearance. To determine the resistance of Plasmodium to halibuterin, the following three points should be met: 1)