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采用鼠深Ⅱ度烫伤模型，160只SD大鼠随机分成丹参组和生理盐水组，测定创面组织内皮素（ET）含量、一氧化氮（NO）含量、含水量及超氧歧化酶（SOD）活性，以探讨丹参提高烫伤创面组织活力的机制。结果示烫伤后两组ET、NO含量伤后上升，ET4h达到峰值，NO8h达到；伤后8h丹参组NO／ET比例就趋向于伤前的2．87，而生理盐水组伤后72h仍明显高于2．87；生理盐水组含水量伤后4h、24h和48h明显高于丹参组；生理盐水组SOD活性下降后恢复慢，而丹参组一度下降后很快回升。丹参组创面愈合时间较短，且无瘢痕形成、毛发生长如常。提示烫伤后丹参通过优化NO／ET比例，降低ET与NO合成量，提高创面组织活力，减轻烫伤早期创面进行性损害作用，创面愈合良好。
Using a rat deep II degree scald model, 160 SD rats were randomly divided into Salvia miltiorrhiza group and saline group, and the endothelin (ET) content, nitric oxide (NO) content, water content, and superoxide dismutase (SOD) were measured. Activity, to explore Salvia miltiorrhiza improve the mechanism of burn wound tissue. The results showed that the ET and NO levels in the two groups increased after injury, ET4h peaked, and NO8h reached; the NO/ET ratio in the Salvia miltiorrhiza group tended to 2.87 before the injury at 8 hours after injury, while it was still significantly higher at 72 hours after the injury in the saline group. At 2.87, the water content of the saline group was significantly higher than that of the Salvia miltiorrhiza group at 4 h, 24 h, and 48 h after injury; the SOD activity of the saline group decreased slowly after recovery, while the Salvia miltiorrhiza group soon recovered after a drop. Salvia miltiorrhiza group wound healing time is short, and no scar formation, hair growth as usual. It is suggested that Salvia miltiorrhiza can improve the NO/ET ratio, reduce the synthesis of ET and NO, increase the vitality of wound tissue, reduce the progressive damage of early burn wounds, and heal the wounds well.