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Objective To study the expressions of MMP-2 and TIMP-2 in pancreatic carcinoma and their relationship with tumor invasion,local metastasis and prognosis of the carcinoma.Methods The expressions of MMP-2 and TIMP-2 were examined in 32 patients with pancreatic carcinomas by S-P immunohistochemical technique and the correlation with pathological tumor parameters were analyzed.Survival analysis was made by using the Kaplan-Meier method.Results The positive rates of MMP-2,TIMP-2 in 32 patients with pancreatic carcinoma were 56.25% and 75.00%,which were significantly higher than those of the controls(P<0.05).Expressions of MMP-2 and TIMP-2 were independent of sex,age,histological grading and type,but well correlated with the lymph node metastasis and TNM clinical staging(Ⅰ and Ⅲ,Ⅱ and Ⅲ).There was a significant association between MMP-2,TIMP-2 and prognosis in pancreatic carcinoma.Conclusion MMP-2 and TIMP-2 might be useful markers for biological aggressiveness of this malignancy and might contribute to the invasive properties of pancreatic carcinoma,which can be used to evaluate the prognosis of patients.
Objective To study the expressions of MMP-2 and TIMP-2 in pancreatic carcinoma and their relationship with tumor invasion, local metastasis and prognosis of the carcinoma. Methods The expressions of MMP-2 and TIMP-2 were examined in 32 patients with pancreatic carcinomas by SP immunohistochemical technique and the correlation with pathological tumor parameters were analyzed. Survival analysis was made by using the Kaplan-Meier method. Results The positive rates of MMP-2, TIMP-2 in 32 patients with pancreatic carcinoma were 56.25% and 75.00% , which were significantly higher than those of the controls (P <0.05). Expressions of MMP-2 and TIMP-2 were independent of sex, age, histological grading and type, but well correlated with the lymph node metastasis and TNM clinical staging ( I and III, II and III). There was a significant association between MMP-2, TIMP-2 and prognosis in pancreatic carcinoma. Conclusions MMP-2 and TIMP-2 might be useful markers for biological aggressiveness of this malignancy and might contribute to the invasive properties of pancreatic carcinoma, which can be used to evaluate the prognosis of patients.