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近年来人们对食物-药物间的相互作用进行了广泛研究,但因其作用极为复杂,故尚不能用来指导临床实践。食物能通过各种不同机理而影响药物的吸收,最终改变药物的吸收速率和生物利用度。形成难于吸收的络合物就是其中一个重要机理。牛奶(钙)、铁盐及许多含多价阳离子的制酸剂,干扰四环素的吸收就是一个典型例子。钙、铁、镁、锌和铝等阳离子同样也能明显地影响氟喹诺酮的吸收。
In recent years, extensive research has been conducted on the food-drug interactions, but because of its extremely complicated role, it can not be used to guide clinical practice. Food can affect drug absorption through a variety of different mechanisms, ultimately changing the rate of absorption and bioavailability of the drug. The formation of complexes that are difficult to absorb is one of the important mechanisms. Milk (calcium), iron salts and many antacids containing polyvalent cations interfere with tetracycline absorption is a classic example. Cations such as calcium, iron, magnesium, zinc and aluminum can also significantly affect fluoroquinolone uptake.