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目的研究原发性高血压(EH)患者臂踝脉搏波传导速度(ba PWV)、颈动脉内膜中膜厚度(c IMT)与同型半胱氨酸(Hcy)、D-二聚体的相关性。方法选择246例EH患者,测量ba PWV、c IMT,分别按两者数值分组,ba PWV<1700 cm/s为动脉僵硬度正常组、≥1700 cm/s为动脉僵硬度异常组;c IMT<0.9 mm为正常组、0.9≤c IMT<1.2 mm为增厚组、c IMT≥1.2 mm为斑块组。同时检测Hcy、D-二聚体及血生物化学指标水平。结果动脉僵硬度异常组Hcy、D-二聚体水平较动脉僵硬度正常组显著增高(P<0.05);c IMT正常组、增厚组、斑块组Hcy、D-二聚体水平也依次增高(P<0.05)。偏相关分析显示,在排除年龄、体重、血脂、血糖后,ba PWV与Hcy、D-二聚体呈正相关(r=0.18、r=0.32,P<0.05),c IMT与Hcy、D-二聚体呈正相关(r=0.56、r=0.27,P<0.05),ba PWV与c IMT也呈正相关(r=0.29,P<0.05)。结论 Hcy的增加和D-二聚体的升高与预示动脉病变的ba PWV、c IMT存在相关性。
Objective To investigate the relationship between brachial-ankle pulse wave velocity (ba PWV), carotid intima-media thickness (c IMT) and homocysteine (Hcy) and D-dimer in patients with essential hypertension (EH) Sex. Methods A total of 246 EH patients were selected and ba PWV and c IMT were measured. The PW PWV and c IMT were grouped according to the two values. Ba PWV <1700 cm / s was normal arterial stiffness group and ≥1700 cm / s was abnormal arterial stiffness group. C IMT < 0.9 mm for the normal group, 0.9 ≤ c IMT <1.2 mm for the thickening group, c IMT ≥ 1.2 mm for the plaque group. Simultaneous detection of Hcy, D-dimer and blood biochemical indicators. Results The levels of Hcy and D-dimer in the group with abnormal arterial stiffness were significantly higher than those in the normal group (P <0.05). The levels of Hcy and D-dimer in c IMT normal group, thickening group and plaque group were in turn Increased (P <0.05). Partial correlation analysis showed that ba PWV was positively correlated with Hcy and D-dimer (r = 0.18, r = 0.32, P <0.05) after excluding age, weight, (R = 0.56, r = 0.27, P <0.05). There was also a positive correlation between ba PWV and c IMT (r = 0.29, P <0.05). Conclusions The increase of Hcy and the increase of D-dimer are correlated with ba PWV and c IMT which indicate arterial disease.