论文部分内容阅读
目的:探讨支气管哮喘患儿血清25羟维生素D3[25-(OH)D3]水平对病情严重程度及临床转归的影响。方法:选取144例支气管哮喘患儿为研究对象,依据病情严重程度分为轻度间歇组、轻度持续组、中度持续组及重度持续组,选取60例健康儿童作为对照组,检测血清25-(OH)D3水平;在治疗4周后应用儿童哮喘控制测试评分系统(C-ACT)对患儿哮喘控制情况给予评价,将所有患儿分为未控制组、部分控制组及完全控制组,比较各组血清25-(OH)D3水平的差异。结果:对照组、轻度间歇组、轻度持续组、中度持续组、重度持续组5组之间血清25-(OH)D3水平存在显著的统计学差异(P<0.05),从对照组到重度持续组血清25-(OH)D3水平逐渐降低(P<0.05);完全控制组、部分控制组及未控制组三组血清25-(OH)D3水平亦存在显著的统计学差异(P<0.05),从完全控制组到未控制组血清25-(OH)D3水平亦呈现逐渐降低趋势(P<0.05);血清25-(OH)D3水平与病情严重程度呈负相关(rs=-0.489,P<0.05),血清25-(OH)D3水平与C-ACT评分亦呈负相关(rs=-0.470,P<0.05);随着血清25-(OH)D3水平下降程度的加重,患儿发生重度持续发作、出现C-ACT评分<19分的风险值(OR)则逐渐增大。结论:血清25-(OH)D3水平与哮喘患儿病情严重程度及病情控制情况密切相关,早期血清维生素D水平对于哮喘患儿病情及近期预后具有一定意义。
Objective: To investigate the effect of serum 25-hydroxyvitamin D3 [25- (OH) D3] on the severity and clinical outcome in children with bronchial asthma. Methods: A total of 144 children with bronchial asthma were enrolled in this study. The patients were divided into mild intermittent group, mild persistent group, moderate persistent group and severe persistent group according to the severity of the disease. 60 healthy children were selected as the control group, serum 25 - (OH) D3 levels. After 4 weeks of treatment, asthma control in children was evaluated by C-ACT, and all children were divided into uncontrolled group, partial control group and complete control group , The difference of serum 25- (OH) D3 level in each group was compared. Results: Serum levels of 25- (OH) D3 in control group, mild intermittent group, mild persistent group, moderate persistent group and severe persistent group were significantly different (P <0.05) The levels of serum 25- (OH) D3 decreased gradually in severe persistent group (P <0.05). There was also significant difference in serum 25- (OH) D3 levels between control group, control group and uncontrolled group <0.05). The level of serum 25- (OH) D3 also gradually decreased from the complete control group to the uncontrolled group (P <0.05). The level of serum 25- (OH) D3 was negatively correlated with the severity of illness (rs = (OH) D3 level was negatively correlated with C-ACT score (rs = -0.470, P <0.05). With the decreasing of serum 25- (OH) Severe persistent episodes occurred in children with C-ACT scores <19 points (OR) gradually increased. Conclusion: The level of serum 25- (OH) D3 is closely related to the severity of illness and disease control in children with asthma. Early serum vitamin D level has certain significance for the condition and prognosis of children with asthma.