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目的：：研究吸烟患者气管内插管( ETT)套囊内注入碱化利多卡因能否减轻术后呛咳和咽喉疼的发生。方法：50例在全麻下行外科手术的吸烟患者随机分为利多卡因组( L组)和对照组( S组)。 L组患者ETT套囊内注入碱化的2%利多卡因,S组ETT套囊内注入0.9%氯化钠注射液。记录两组患者麻醉持续时间、麻醉终止到气管拔管的时间,比较两组患者术后呛咳和咽喉疼发生率。结果：L组在降低患者术后呛咳方面优于S组(P<0.001),在麻醉恢复室(PACU)内术后咽喉疼的发生率L组患者也明显低于S组(P<0.05)。拔管后24 h,两组患者咽喉疼发生率未见明显异常。结论： ETT套囊内应用碱化利多卡因可以降低吸烟患者术后咽喉疼和呛咳的发生率。“,”Objective:To evaluate the effect of alkalinized lidocaine with endotracheal intubation intracuff injection on the occur-rence of cough and sore throat in the smoking patients after operation. Methods:A prospective and double-blind trial was carried out. Totally 50 smoking patients undergoing surgery under general anesthesia were enrolled. The patients were randomly allocated to receive either ETT intracuff injection of alkalinized 2% lidocaine (group L) or ETT intracuff injection of 0. 9% saline (group S). The inci-dence of cough and sore throat in the two groups was compared. The duration of anesthesia and the time between anesthesia termination and extubation were also recorded. Results:Group L was superior to group S in reducing cough (P<0. 001). The incidence of postop-erative sore throat in group L was significantly lower than that in group S in the post-anesthesia care unit (PACU) (P0. 05). Conclusion:The intracuff injection of alkalinized lidocaine is superior to saline in decreasing the incidence of postoperative cough and sore throat in smoking patients.