蛇床子素30μmol·L~(-1)及100μmol·L~(-1)使NE、CaCl_2和高K~+除极化所致的家兔主动脉条收缩量—效曲线右移,最大反应降低.表明蛇床子素有松弛血管平滑肌作用,并与Ca~(2+)呈非竞争性拮抗作用.和阻滞α受体或激动β受体无关;选择性作用于电位依赖性Ca~(2+)通道,抑制细胞外Ca~(2+)内流;在100μmol·L~(-1)时,明显减弱NE诱导的依赖细胞内Ca~(2+)收缩。证明蛇床子素松弛血管平滑肌作用可能与其Ca~(2+)拮抗作用有关。 The osthole contraction-effect curve of rabbit aorta induced by NE, CaCl 2 and high K ~ + depolarization shifted to the right when the osthole was 30μmol·L -1 and 100μmol·L -1, Decreased, indicating that osthole has the effect of relaxing vascular smooth muscle and has a noncompetitive antagonistic effect with Ca 2+, and has no relation with blocking α receptor or activating β receptor. It selectively acts on potential-dependent Ca ~ (-) (2+) channels, and inhibited the influx of extracellular Ca ~ (2+). At 100μmol·L ~ (-1), NE-induced Ca ~ (2+) -dependent cell contraction was significantly attenuated. Proved osthole relaxation of vascular smooth muscle may be related to its Ca ~ (2 +) antagonistic effect.