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[目的]分析血清甲胎蛋白(AFP)对慢加急性肝衰竭患者预后的意义。[方法]回顾性分析89例慢加急性肝衰竭患者,按照3个月预后分为存活组(51例)和死亡组(38例),将2组患者再按照AFP值各自分为A亚組(AFP<20ng/ml)、B亚組(≥20~<200ng/ml)、C亚組(≥200ng/ml),入院1周内测量AFP,观察AFP与患者预后的关系。[结果]存活组与死亡组患者AFP水平的比较差异有统计学意义(P<0.05);存活组患者疗效比较,C亚组与A、B亚组比较差异有统计学意义(P<0.05);死亡组患者不同时间段死亡人数的比较,各亚组差异无统计学意义(P>0.05),但C亚组患者的生存期要长于A、B亚组患者。[结论]AFP升高与否与慢加急性肝衰竭患者的预后密切相关,AFP升高越明显,提示预后越好。
[Objective] To analyze the significance of serum alpha-fetoprotein (AFP) in the prognosis of patients with acute and chronic liver failure. [Methods] A total of 89 patients with acute and chronic liver failure were retrospectively analyzed. According to their 3-month prognosis, they were divided into survival group (51 cases) and death group (38 cases) .According to AFP value, (AFP <20ng / ml), subgroup B (≥20 ~ <200ng / ml) and subgroup C (≥200ng / ml) .AFP was measured within 1 week before admission to observe the relationship between AFP and prognosis. [Results] There was significant difference in AFP level between survivors and death patients (P <0.05). There was significant difference between A group and B subgroups in survivors (P <0.05) . There was no significant difference in the death toll between death group and different subgroups (P> 0.05), but the survival time of patients in subgroup C was longer than that of subgroups A and B. [Conclusion] The increase of AFP is closely related to the prognosis of patients with acute and chronic liver failure. The higher the AFP, the better the prognosis.