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目的:观察枯草杆菌二联活菌颗粒在儿童腹型过敏性紫癜(HSP)治疗中的辅助作用。方法:将139例腹型HSP住院患儿中完成研究的125例纳入研究对象,采用随机数字表法随机分为观察组70例和对照组55例。对照组给予西咪替丁、维生素C、钙剂及糖皮质激素等综合治疗,合并感染者给予抗生素治疗,观察组在对照组治疗基础上加服枯草杆菌二联活菌颗粒,年龄4～6岁,1 g/次,～12岁,1.5 g/次,均为3次/d,7 d为1个疗程。观察两组患儿消化道症状(腹痛、呕吐、便血等)的变化、治疗1周后唾液分泌型IgA(sIgA)含量的变化及1周后的临床疗效。结果:观察组消化道症状消失时间均短于对照组(P<0.01)。1周后,观察组sIgA与治疗前比较显著升高(t=4.556,P<0.01),而对照组与治疗前比较差异无统计学意义(t=0.914,P>0.05),总有效率观察组95.71%,对照组81.82%,两组比较差异有统计学意义(χ2=4.978,P<0.05)。结论:枯草杆菌二联活菌颗粒可提高消化道粘膜的免疫功能,佐治儿童腹型HSP,可较快缓解消化道症状,防止消化道出血,从而缩短病程。
Objective: To observe the auxiliary role of Bacillus subtilis bivalent live granules in the treatment of children with abdominal Henoch-Schonlein purpura (HSP). Methods: A total of 125 patients completed the study of 139 cases of abdominal HSP inpatients were enrolled in the study, and randomly divided into observation group (n = 70) and control group (n = 55) by random number table method. Control group was given cimetidine, vitamin C, calcium and glucocorticoid and other comprehensive treatment of patients with infection were given antibiotics, the observation group in the control group based on the treatment plus Bacillus subtilis live together particles, aged 4 to 6 Year old, 1 g / time, ~ 12 years old, 1.5 g / time, all 3 times / d, 7 d for a course of treatment. The changes of gastrointestinal symptoms (abdominal pain, vomiting, blood in the stool, etc.) in both groups were observed. The change of sIgA in saliva and the clinical effect after 1 week were observed. Results: The disappearance time of gastrointestinal symptoms in observation group was shorter than that in control group (P <0.01). After 1 week, the sIgA in the observation group was significantly higher than that before treatment (t = 4.556, P <0.01), while there was no significant difference between the control group and before treatment (t = 0.914, P> 0.05) 95.71% in the control group and 81.82% in the control group. There was significant difference between the two groups (χ2 = 4.978, P <0.05). Conclusion: Bacillus subtilis bivalent granules can enhance the immune function of gastrointestinal mucosa. Gastroenterology in children with abdominal heat type HSP can relieve digestive tract symptoms and prevent gastrointestinal bleeding, thus shortening the course of disease.