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结直肠癌(colorectal cancer,CRC)是我国的高发肿瘤之一。近104年来,我国CRC的发病率及死亡率均位居恶性肿瘤的前5位,且每年其发病率及死亡率均在增高~([1])。譬如,2000-2006年期间CRC的发病率以每年4.2%的速度在增高,2006-2011年期间以每年1.3%的速度在增高~([1])。然而在美国,在50~64岁人群中,CRC的发病二率以每年1.4%的速度在降低,在≥65岁人群中以每年3.1%的速度在降低;死亡率也1呈现相同的趋势~([2]).此外,CRC的发病率和死亡率均以阿拉斯加人居首,
Colorectal cancer (CRC) is one of the high-grade tumors in our country. In the past 104 years, the morbidity and mortality of CRC in China are among the top 5 malignant tumors, and the incidence and mortality rate of CRC are increasing every year ([1]). For example, the incidence of CRC during the period 2000-2006 increased at a rate of 4.2% per year, and increased at a rate of 1.3% per year during the period 2006-2011 ([1]). However, in the United States, the incidence of CRC in the 50-64-year-old population is decreasing at a rate of 1.4% per year, and is decreasing at a rate of 3.1% per year in the ≥65-year-old population; the mortality rate 1 also shows the same trend. ([2]). In addition, the morbidity and mortality of CRC are the highest in Alaska.