对颌下腺的实验性研究已经证实它和其它内分泌和激素诸因素的从属关系。切除甲状腺和服用硫氧嘧啶衍化物会导致颌下腺萎缩,服用甲状腺浸出物则会导致颌下腺肥大。另一方面,服用雌激素会使颌下腺的体积缩小及功能降低。男性颌下腺的容量及分泌活动要大大超过女性。很多种物质牵涉到涎腺肿瘤的发生。已经证实给老鼠局部注射DMBA可诱发鳞癌或腺癌。系统性服用氟尿嘧啶,氨甲喋呤和环磷酰胺会促进这些癌的产生和扩散。切除 Experimental studies of the submandibular gland have confirmed its affiliation with other endocrine and hormone factors. Resection of the thyroid gland and administration of thiouracil derivatives can lead to atrophy of the submandibular glands. Taking thyroid leachates can lead to hypertrophy of the submandibular glands. On the other hand, taking estrogen reduces the volume and function of the submandibular glands. Male submandibular glands have much more capacity and secretion than women. Many kinds of substances involve the occurrence of salivary gland tumors. Local injections of DMBA to mice have been shown to induce squamous or adenocarcinoma. Systemic use of fluorouracil, methotrexate and cyclophosphamide promote the development and spread of these cancers. resection