血浆渗透压是由血浆中电解质离子和小分子有机物形成的晶体渗透压与血浆蛋白形成的胶体渗透压之和，它是维持细胞内外液体电解质平衡的主要参数。国内已有对其他疾病血浆渗透压的研究报导，本文对新生儿高胆红素血症（以下简称高胆）患儿的血浆渗透压及其主要组成成分进行监测 Plasma osmolality is the sum of the osmotic pressure of the crystal formed by the electrolyte in the plasma and small organic molecules and the colloid osmotic pressure formed by the plasma protein. It is the main parameter for maintaining the electrolyte balance inside and outside the cell. In China, there have been reports of plasma osmolality in other diseases. In this paper, the plasma osmolality and its main components in neonates with hyperbilirubinemia (hereinafter referred to as hypercholesterolemia) were monitored