论文部分内容阅读
目的对肌红蛋白(Mb)、肌酸激酶同工酶(CK-MB)和心肌肌钙蛋白I(cTnI)单项定量检测及联合检测进行比较,为急性心肌梗死(AMI)的早期诊断和预后评估提供更准确合理的检测指标。方法对239例临床征象高度可疑的AMI患者在入院后24h内检测cTnI、Mb和CK-MB,比较它们对AMI诊断的敏感性和特异性,并进行组合。结果在入院后24h内cTnI、Mb、CK-MB对AMI的敏感性分别为96.8%、100%和76.6%,特异性分别为100%、89.4%和97.6%。AMI患者死亡率随着cTnI水平的升高而显著增加。cTnI、Mb、CK-MB联合检测,对AMI的敏感性为100%,特异性为88.2%,阳性预期值为100%,阴性预期值为84.2%。结论cTnI、Mb和CK-MB联合检测,结果其敏感性提高到100%,阳性预期值达100%,其综合特异性也可达88.2%,同时对预后、再梗死发生及疗效有很好的观察效果。
Objective To compare the single quantitative detection and the combined detection of myoglobin (Mb), creatine kinase (CK-MB) and cardiac troponin I (cTnI) in early diagnosis and prognosis of acute myocardial infarction (AMI) Evaluation provides more accurate and reasonable detection index. Methods 239 patients with highly suspicious clinical signs of AMI were examined for cTnI, Mb and CK-MB within 24 hours after admission. Their sensitivity and specificity for diagnosis of AMI were compared and combined. Results The sensitivity of cTnI, Mb and CK-MB to AMI was 96.8%, 100% and 76.6% respectively, and the specificity was 100%, 89.4% and 97.6% respectively within 24 hours after admission. Mortality in AMI patients increased significantly with increasing cTnI levels. The combined detection of cTnI, Mb and CK-MB had a sensitivity of 100% and a specificity of 88.2% for AMI, with a positive predictive value of 100% and a negative predictive value of 84.2%. Conclusions The combined detection of cTnI, Mb and CK-MB results in a sensitivity of 100%, a positive predictive value of 100% and a combined specificity of 88.2%, with good prognosis and reinfarction outcome Observe the effect.