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目的:观察复方丹参注射液在治疗新生儿缺氧缺血性脑病(HIE)中的疗效。方法:治疗组:29例,综合治疗基础上加用复方丹参注射液,0.2～0.4mL/(kg.d)加入5%葡萄糖溶液30～50mL静滴,每日1次,连用7～10d为1疗程。对照组:29例,除复方丹参注射液外,余治疗相同。观察两组患儿治疗后的显效率和总有效率。结果:治疗组显效18例(62.1%),有效8例(27.6%),总有效率为89.7%;对照组显效10例(34.5%),有效12例(41.4%),总有效率75.9%。两组在显效率及总有效率之间的差异均有显著意义(P<0.05)。不良反应:两组均未发现明显不良反应。结论:复方丹参注射液能有效改善患儿的临床神经症状和体征,且用药安全,未发现不良反应,值得临床推广应用。
Objective: To observe the effect of Fufang Danshen injection in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Methods: In the treatment group, 29 cases were treated with Fufang Danshen injection at the dose of 0.2 ~ 0.4mL / (kg · d) on the basis of comprehensive treatment. 30-50ml of 5% dextrose solution was intravenously administered once daily for 7-10 days 1 course of treatment. Control group: 29 cases, except compound Danshen injection, more than the same treatment. Observation of two groups of children after treatment markedly effective and total effective rate. Results: The effective rate of the treatment group was 18 (62.1%), effective rate was 8 (27.6%), and the total effective rate was 89.7%. The control group was markedly effective in 10 cases (34.5%), effective in 12 cases (41.4% . The difference between the two groups in significant efficiency and total effective rate was significant (P <0.05). Adverse reactions: No significant adverse reactions were found in both groups. Conclusion: Salvia miltiorrhiza injection can effectively improve the clinical neurological symptoms and signs of children, and medication safety, no adverse reactions, it is worth promoting the clinical application.