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目的 :探讨冠心病 (CHD)患者血清血管内皮生长因子 (VEGF)水平与冠状动脉病变的关系。方法 :采用酶联免疫吸附法 (ELISA)检测了 12 4例经冠状动脉造影证实有一支以上主要冠状动脉狭窄≥ 5 0 %的CHD患者血清VEGF水平 ,并作相关分析。结果 :CHD组血清VEGF水平明显高于正常对照组〔(2 93.2± 12 6 .3)ng/L∶(12 0 .1± 31.5 )ng/L ,P <0 .0 1〕 ,双支和三支血管病变患者血清VEGF水平高于单支组〔(2 83.4± 85 .0 )ng/L ,(398.1± 10 5 .5 )ng/L∶ (191.7± 2 7.3)ng/L ,P <0 .0 1〕 ,随着血管狭窄程度的加重 ,血清VEGF水平升高越明显 ,两者呈显著正相关 (r =0 .78,P <0 .0 0 1) ,CHD并发高血压和 (或 )糖尿病对血清VEGF水平无显著影响 (P >0 .0 5 )。结论 :CHD患者血清VEGF水平升高 ,其升高程度与冠状动脉病变程度有良好的相关性
Objective: To investigate the relationship between serum vascular endothelial growth factor (VEGF) and coronary artery disease in patients with coronary heart disease (CHD). Methods: The levels of serum VEGF in 12 4 CHD patients with more than one coronary artery stenosis ≥50% confirmed by coronary angiography were detected by enzyme - linked immunosorbent assay (ELISA). Results: The serum level of VEGF in CHD group was significantly higher than that in control group [(93.2 ± 12.6.3) ng / L: (120.1 ± 31.5) ng / L, P <0.01] The level of serum VEGF in patients with three-vessel disease was significantly higher than that in patients in the single-vessel group (2 83.4 ± 85.0 ng / L, 398.1 ± 105.5 ng / L and 191.7 ± 2 7.3 ng / L, P < 0 0 01), with the severity of vascular stenosis, serum VEGF levels increased more significantly, both were significantly correlated (r = 0.78, P <0.001), CHD complicated by hypertension and ( Or diabetes did not significantly affect serum VEGF levels (P> 0.05). Conclusion: The serum level of VEGF in CHD patients is elevated, and the correlation between the level of VEGF and the severity of coronary artery disease is good