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目的探讨轻型地中海贫血孕妇妊娠期血红蛋白(Hb)和血清铁蛋白(SF)的变化及其临床意义。方法对40例轻型地中海贫血孕妇(贫血组)的临床资料进行回顾性分析;另选取同期来本院产前检查的40例健康孕妇作为对照组。结果组内比较,两组孕妇孕早期、中期、晚期Hb、SF含量均逐渐降低,但差异均不显著(P>0.05)。组间比较,贫血组孕早期、中期、晚期Hb、SF含量均显著低于对照组(P<0.05),下降幅度均显著高于对照组(P<0.05);贫血组产后出血量、剖宫产率、羊水过多/过少发生率、早产儿、足月低体重儿比例均显著高于对照组(P<0.05),新生儿出生体质量显著低于对照组(P<0.05)。结论轻型地中海贫血孕妇妊娠期Hb、SF含量较低,对妊娠结局造成不良影响。
Objective To investigate the changes of hemoglobin (Hb) and serum ferritin (SF) in pregnant women with mild thalassemia and their clinical significance. Methods The clinical data of 40 pregnant women with anemia of thalassemia (anemia group) were retrospectively analyzed. Forty healthy pregnant women who were in our hospital during the same period were selected as the control group. Results Compared with the control group, the levels of Hb and SF in the early, middle, late pregnant women in both groups gradually decreased, but the differences were not significant (P> 0.05). The levels of Hb and SF in the first trimester, middle and late trimester of the anemia group were significantly lower than those of the control group (P <0.05), and the decreasing range was significantly higher than that of the control group (P <0.05). The incidence of postpartum hemorrhage, The rates of birth rate, the rate of oligohydramnios / oligohydramnios, preterm infants and full-term low birth weight infants were significantly higher than those of the control group (P <0.05). The newborns’ birth mass was significantly lower than that of the control group (P <0.05). Conclusion Pregnant women with mild thalassemia have lower levels of Hb and SF during pregnancy, which have adverse effects on pregnancy outcome.