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目的:观察老年高血压病患者炎症因子变化、血小板活化和血管内皮细胞损伤。方法:选择35例1级、2级老年高血压病患者和30例老年正常对照者,测定血浆单核细胞趋化蛋白1(MCP-1)、A颗粒膜蛋白-140(GMP-140)和vonWillebrand因子(vWF)含量进行分析。结果:老年高血压病组血浆MCP-1及GMP-140含量较正常对照组高,差异有显著性(P<0.05);血浆vWF含量较正常对照组高,差异有非常显著性(P<0.01)。结论:老年高血压病患者有明显的炎症反应、血小板活化和血管内皮细胞损伤。
Objective: To observe the changes of inflammatory factors, platelet activation and vascular endothelial cell injury in elderly patients with hypertension. Methods: Thirty-five patients with grade 1 and 2 hypertension and 30 elderly controls were enrolled in this study. Plasma concentrations of monocyte chemoattractant protein 1 (MCP-1), granule membrane protein-140 (GMP-140) von Willebrand factor (vWF) content analysis. Results: The content of plasma MCP-1 and GMP-140 in elderly patients with hypertension was significantly higher than that of the control group (P <0.05), and the plasma vWF content was significantly higher than that of the normal control group (P <0.01) ). Conclusion: Elderly hypertensive patients have obvious inflammatory reaction, platelet activation and vascular endothelial cell injury.