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[目的]了解HPV检测在辽宁省沈阳市苏家屯地区农村妇女宫颈癌筛查过程中的作用,为宫颈癌筛查提供科学依据。[方法]对2014~2015年间自愿接受宫颈癌筛查的35~64岁农村常住妇女,进行调查、取样和HPV检测。[结果]对10 000名35~64岁妇女进行宫颈癌筛查,发现宫颈癌癌前病变80人(其中CIN1为36人,CIN2为30人,CIN3为14人),宫颈癌3人。高危型HPV阳性共1209人,高危型HPV阳性感染率随年龄的升高而升高。HPV的感染率随着病变程度加重而升高;宫颈上皮内瘤变和宫颈癌组HPV 16型的比例显著性高于其他组。[结论]HPV检测在宫颈癌的筛查过程中对提高早诊率具有重要的意义。
[Objective] To understand the role of HPV testing in cervical cancer screening in rural women in Sujiatun, Shenyang, Liaoning Province, and provide a scientific basis for cervical cancer screening. [Methods] The survey of rural women aged 35-64 years who volunteered for cervical cancer screening between 2014 and 2015 was conducted, sampling and HPV testing. [Results] Cervical cancer screening was performed in 10 000 women aged 35-64 years. There were 80 precancerous lesions of cervical cancer (CIN1 was 36, CIN2 was 30, CIN3 was 14) and cervical cancer was 3. A total of 1209 high-risk HPV positive patients, high-risk HPV-positive infection rate increased with age. HPV infection rate increased with the severity of the disease; cervical intraepithelial neoplasia and cervical cancer HPV16 type ratio was significantly higher than the other groups. [Conclusion] HPV testing plays an important role in improving the rate of early diagnosis of cervical cancer during screening.