本文综述了溶栓疗法治疗急性脑梗塞的机理、动物实验和临床研究、血管再通的后果、溶栓药物的选择和剂量、以及影响疗效的因素。认为溶栓疗法对急性脑梗塞有显著疗效(尤其在发病6h 以内治疗),开始治疗时间越早,疗效越好,并发脑出血的可能性越小。提示溶栓疗法是目前唯一从根本上治疗脑梗塞的方法,提高疗效的关键是早期治疗。 This article reviews the mechanism of thrombolytic therapy in the treatment of acute cerebral infarction, animal experiments and clinical studies, the consequences of recanalization, the choice and dosage of thrombolytic drugs, and the factors that affect the efficacy. That thrombolytic therapy has a significant effect on acute cerebral infarction (especially within 6h onset of treatment), the beginning of the treatment time, the better, the possibility of cerebral hemorrhage is less likely. Tip thrombolytic therapy is the only way to fundamentally the treatment of cerebral infarction, the key to improving the efficacy of early treatment.