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目的观察沐舒坦对促进胎肺成熟和降低早产儿呼吸窘迫综合征(RDS)的疗效。方法选择2013年2月至2014年2月在汕尾市第二人民医院行计划早产分娩且单胎妊娠的产妇106例,按照随机数字表法随机分为两组,每组53例。对照组产妇产前给予地塞米松静脉滴注,17例RDS患儿行常规对症支持治疗;研究组产妇产前给予沐舒坦静脉滴注,9例RDS患儿行沐舒坦治疗,观察不同孕周早产儿的胎肺成熟、动脉血气指标与疗效。结果研究组28~31周时的RDS、Apgar评分≤6.9分、L/S<1.5的发生率为40.00%、33.33%、20.00%,比对照组(58.82%、76.47%、47.06%)低,31~34周时的发生率为25.00%、8.33%与8.33%,比对照组(50.00%、33.33%与41.67%)低,差异有统计学意义(P<0.05);研究组患儿治疗12 h、48 h的Pa O2、Pa CO2与p H值均明显优于对照组,差异有统计学意义(P<0.05);研究组机械通气、氧疗与住院时间均显著短于对照组,差异有统计学意义(P<0.05)。结论沐舒坦防治早产儿呼吸窘迫综合征的临床效果显著。
Objective To observe the effect of ambroxol on promoting fetal lung maturation and reducing respiratory distress syndrome (RDS) in preterm infants. Methods From February 2013 to February 2014, 106 maternal mothers who planned delivery and singleton pregnancy in the Second People’s Hospital of Shanwei City were randomly divided into two groups (n = 53) according to random number table. The control group of mothers prenatal dexamethasone intravenous infusion, 17 cases of RDS children with conventional symptomatic and supportive treatment; the study group of mothers prenatal given ambroxol intravenous infusion, 9 cases of RDS children with mucosolvan treatment, observed different gestational weeks Premature infant fetal lung maturation, arterial blood gas index and efficacy. Results The incidences of RDS and Apgar score ≤6.9 and L / S <1.5 in study group from 28 to 31 weeks were 40.00%, 33.33% and 20.00%, respectively, which were lower than those in control group (58.82%, 76.47%, 47.06% The incidence rates at 31-34weeks were 25.00%, 8.33% and 8.33%, which were lower than those in control group (50.00%, 33.33% and 41.67% respectively), with significant difference (P <0.05) Pa, PaCO 2 and p H at 48 h were significantly better than those in the control group (P 0. 05). The mechanical ventilation, oxygen therapy and hospital stay in the study group were significantly shorter than those in the control group There was statistical significance (P <0.05). Conclusions Mucosolvan is effective in preventing and treating respiratory distress syndrome in premature infants.