论文部分内容阅读
中枢神经介质的研究近年来进展较快,目前已经肯定的中枢介质可分为3大类:乙酰胆硷(Ach)、单胺类和氨基酸类。至今已有充分证据把谷氨酸、r-氨基丁酸(GABA)和甘氨酸列为中枢介质,而天门冬氨酸和牛磺酸等也可能是中枢介质。尤其GABA已被证实是脑中重要的抑制性介质,有人预料它在癫痫发病机制中的地位可能比Ach、单胺类介质重要得多。氨基酸介质的研究不仅对阐明小儿癫痫和其他惊厥性疾病的发病机制很重要,进而也能指导临床诊断和提高癫痫疗效。
Central nervous system research has progressed rapidly in recent years. At present, central media that have been affirmed can be divided into three categories: acetylcholine (Ach), monoamines and amino acids. So far there is sufficient evidence of glutamate, r-aminobutyric acid (GABA) and glycine as the central medium, and aspartic acid and taurine may also be the central medium. In particular, GABA has been shown to be an important inhibitory mediator of the brain and it is expected that its status in the pathogenesis of epilepsy may be more important than the Ach, monoamine mediator. Amino acid media research not only to elucidate the pathogenesis of epilepsy and other convulsions in children is very important, and thus also can guide the clinical diagnosis and improve the efficacy of epilepsy.