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用琼脂糖凝胶电永的方法，研究了青藏高原喜马拉雅旱獭鼠疫自然疫源地的９１４株鼠疫菌，共观察到１０种质粒。其中大质粒分子量差异较大，为我国各疫源地中鼠疫菌所含大质粒最独特的地区，其分布特征是：含５２×１０￣６质粒的菌株分布在祁连山南、北麓及青海湖的环湖地区；带６５×１０￣６质粒的菌，主要见于青南高原、当金山口、甘南山地、冈底斯山与喜马拉雅山之间和藏南谷地以及新疆南部的和田、若羌等地；９２×１０￣６质粒分布在藏北高原的以那曲为中心的唐古拉地区，青南高原的南部亦有零星分布。鉴于我国青藏高原喜马拉雅旱獭疫源地鼠疫菌大质粒分子量的差异及分布的特征，提示该疫源地空间结构的复杂性和多样性，具有一定的流行病学意义。
A total of 914 Yersinia pestis isolates from the natural foci of Hamster plague in the Himalayas of the Qinghai-Tibet Plateau were studied by agarose gel electrophoresis. Ten plasmids were observed. Among them, the large difference in the molecular weight of large plasmids is the most unique region of large plastids contained in Y. pestis in all kinds of foci of China. The distribution characteristics are: strains containing 52 × 10 ~ 6 plasmids are distributed in the south of Qilian Mountains and the northern foot of Qinghai Lake Of the lake area; with 65 × 10 ~ 6 plasmid bacteria, mainly seen in the Qingnan Plateau, when the Jinshankou, Gannan mountain, Gangdese and the Himalayas in southern Tibet and southern Xinjiang, Tian, Ruoqiang and other places The 92 × 10-6 plasmids were distributed in the Tanggula region centered on Nagqu in the northern Tibet Plateau and sporadic in the southern part of the Qingnan Plateau. In view of the differences in the molecular weight and the distribution characteristics of the Y. pestis in the Himalayan origin of the Qinghai-Tibet Plateau, it is suggested that the complexity and diversity of the spatial structure of the Y-zone in the Qinghai-Tibet Plateau have some epidemiological significance.