早在上一世纪PaulEhrlich就提出了靶向给药的概念[1]。经过近百年的探索和研究，在靶向释药系统的领域里，不断取得成果和突破，目前，“药物导弹”的设想，正在变为临床实践，成为当今药学研究的重要方向。靶向药物就其导向机理而论可分为被动靶向、主动靶向和物理靶向“。被? As early as the last century PaulEhrlich proposed the concept of targeted drug delivery [1]. After nearly a hundred years of exploration and research, continuous achievements and breakthroughs have been made in the field of targeted drug delivery systems. At present, the concept of “drug missiles” is becoming a clinical practice and has become an important direction in current pharmaceutical research. Targeted drugs in terms of their guiding mechanism can be divided into passive targeting, active targeting and physical targeting.