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目的:探讨肾移植等待患者HLA-A、B、DR抗原位点频率分布特征。方法:选取2013年2月~2015年1月我院收治的待肾移植患者109例为研究对象,采用序列特异性引物聚合酶链反应扩增技术(SSP PCR)检测患者HLA-A、B、DR等位基因并分析其对应血清学特异性。结果:HLA-A抗原频率最高为A11,为56.32%,其次为A2、A24及A33。HLA-B抗原频率最高为B60(29.98%),其次为B46、B13、B75、B58。HLA-DR抗原频率最高为DR12(28.09%)。其次为DR4、DR15、DR9、DR14等。结论:肾移植等待患者HLA-A、B及DR位点频率分布不同,HLA-A11、HLA-B60、HLA-DR12为位点最高频率。
Objective: To investigate the frequency distribution of HLA-A, B and DR antigen in patients waiting for kidney transplantation. Methods: A total of 109 renal transplant recipients admitted to our hospital from February 2013 to January 2015 were enrolled in this study. SSP PCR was used to detect HLA-A, B, DR allele and analyze its corresponding serological specificity. Results: The highest HLA-A antigen frequency was A11, which was 56.32%, followed by A2, A24 and A33. The frequency of HLA-B antigen was highest at B60 (29.98%), followed by B46, B13, B75 and B58. The highest HLA-DR antigen frequency was DR12 (28.09%). Followed by DR4, DR15, DR9, DR14 and so on. Conclusion: The frequencies of HLA-A, B and DR sites in kidney transplantation patients are different, and HLA-A11, HLA-B60 and HLA-DR12 are the highest frequencies.