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目的:β淀粉样蛋白(-βamyloid precursor protein,-βAPP)是已知的参与阿尔茨海默病机制的关键因子。-βAPP是否参与难治性癫痫中的病理机制并不清楚。这项研究在于了解-βAPP的蛋白在难治性癫痫患者术后颞叶皮质和海马组织中的表达是否异常。方法:免疫荧光法半定量测定难治性癫痫患者术后颞叶皮质和海马组织中的-βAPP阳性蛋白的荧光值,并应用统计软件对实验数据进行单因素方差分析。结果:免疫荧光强度值分析结果显示-βAPP在耐药性癫痫脑组织中表达较对照组明显增高且有统计学意义。结论:-βAPP在难治性癫痫脑组织中异常增高,增高的-βAPP可能参与了难治性癫痫的病理机制。
AIM: β-amyloid precursor protein (-βAPP) is a known key factor involved in the pathogenesis of Alzheimer’s disease. It is unclear whether the -APAP is involved in the pathogenesis of refractory epilepsy. The aim of this study is to understand whether the expression of -APAP protein is abnormal in the temporal cortex and hippocampus in patients with refractory epilepsy. Methods: Fluorescence values of β-APP positive protein in temporal cortex and hippocampus of patients with intractable epilepsy were detected by semi-quantitative immunofluorescence method. Statistical software was used to analyze the experimental data by one-way ANOVA. Results: Immunofluorescence intensity analysis showed that the expression of -APAP in the brain tissue of drug-resistant epilepsy was significantly higher than that of the control group. Conclusion: β-APP is abnormally increased in the brain tissue of refractory epilepsy. Increased-βAPP may be involved in the pathological mechanism of refractory epilepsy.