目的:探讨PICC置管相关类过敏反应的临床特点、可能原因和处理方法。方法:回顾性分析浙江大学医学院附属邵逸夫医院2018年10月至2020年2月3 933例PICC置管中发生类过敏反应的27例患者的资料。结果:PICC置管相关类过敏反应发生率为0.69%（27/3 933），临床症状以皮肤系统为主、部分合并呼吸、消化和心血管系统症状。其发生率在性别、诊断和过敏史上差异无统计学意义（n χ2值为2.233、0.839、0.027，均n P>0.05）；<60岁患者的发生率高于≥60岁的患者（n χ2值为12.821，n P<0.01）；2种不同涂层导管的发生率高于无涂层的导管（n χ2值为27.195、84.203，n P0.05). The incidence of patients younger than 60 years old was higher than that of patients older than 60 (n χ2 value was 12.821, n P<0.01); the incidence of two catheters with different coatings was higher than that of uncoated catheters (n χ2 value was 27.195, 84.203, n P<0.01). Twenty six patients continued the catheterization after the symptoms relieved, and one patient stopped the catheterization.n Conclusion:The incidence of anaphylactoid reactions related to PICC, which is more common in catheters or the stylet wire is coated. It is recommended to use a large amount of saline to flush the catheter to reduce or avoid coating materials into the blood, so as to effectively control the occurrence and severity of such complications.