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目的:观察化湿降浊方对高尿酸血症模型大鼠血清尿酸水平及肝脏黄嘌呤氧化酶、肝肾功能的影响。方法:采用次黄嘌呤灌胃联合氧嗪酸钾腹腔注射复制高尿酸血症大鼠模型。以别嘌呤醇为阳性药物对照,研究化湿降浊方(1.2 g/m L)对大鼠组血尿酸(UA)、肝脏黄嘌呤氧化酶(xanthine oxidase,XOD)、尿素氮(BUN)、肌酐(Scr)、谷丙转氨酶(ALT)、谷草转氨酶(AST)的影响。结果:模型组大鼠血清UA、肝脏XOD均显著高于空白组,差异有统计学意义(P<0.01);中药组大鼠血清UA水平低于模型组(P<0.01);中药组、别嘌呤醇组肝脏XOD均明显低于模型组(P<0.01)。各组ALT活性比较,差异无统计学意义(P>0.05);模型组AST、Scr、BUN显著高于空白组(P<0.01);中药组AST的活性明显低于模型组(P<0.01);别嘌呤醇组、中药组Cr、BUN含量显著低于模型组(P<0.01)。结论:化湿降浊方可抑制高尿酸血症模型大鼠肝脏XOD的活性,降低血UA,改善肾功能,对大鼠高尿酸血症有防治作用,并且无肝损性。
Objective: To observe the effect of Huashi Jiangzhuo prescription on serum uric acid level and hepatic xanthine oxidase, liver and renal function in hyperuricemia model rats. Methods: Hypoxemic hypoxemia was induced by intraperitoneal injection of hypoxanthine gavage plus oxynitrate in rats. Taking allopurinol as positive control, the effects of Huashi Jiangzhuo prescription (1.2 g / m L) on serum UA, XOD, BUN, Creatinine (Scr), alanine aminotransferase (ALT), aspartate aminotransferase (AST). Results: Serum UA and liver XOD in the model group were significantly higher than those in the blank group (P <0.01). The serum UA level in the TCM group was lower than that in the model group (P <0.01) The XOD of allopurinol group was significantly lower than that of model group (P <0.01). AST, Scr and BUN in the model group were significantly higher than those in the blank group (P <0.01). The activity of AST in the TCM group was significantly lower than that in the model group (P <0.01) ; Allopurinol group, traditional Chinese medicine group Cr, BUN content was significantly lower than the model group (P <0.01). Conclusion: Huashi Jiangzhuo can inhibit the activity of XOD in the liver of hyperuricemic model rats, lower blood UA, improve renal function, prevent and cure hyperuricemia in rats, and have no hepatic injury.