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目的 :观察糖尿病性脑梗死 (diabeticischemicstroke ,DIS)和非糖尿病性脑梗死 (non diabeticischemicstroke ,NDIS)患者血浆中纤溶酶原激活物 (plasminogenactivator ,PA)及纤溶酶原激活物抑制剂 (plasminogenactivatorinhibitor ,PAI)的动态变化情况。方法 :应用底物发色法测定血浆中PA和PAI活性 ,以观察DIS和NDIS患者血浆PA和PAI活性的动态变化。结果 :NDIS患者血浆中PA活性在4～ 2 1d较非脑梗死患者升高 ;DIS患者的PA活性在 7h～ 2 1d较NDIS患者为低 ,但PAI活性在各组间无明显差异。结论 :DIS患者血浆中PA活性较NDIS患者降低 ,提示其存在纤溶系统激活的紊乱 ,并可能与DIS症状加重有关。
OBJECTIVE: To observe the changes of plasma plasminogen activator (PA) and plasminogen activator inhibitor (PD) in patients with diabetic cerebral infarction (DIS) and non-diabetic cerebral infarction (NDIS) PAI) dynamic changes. Methods: The activity of PA and PAI in plasma was measured by substrate chromogenic method to observe the dynamic changes of plasma PA and PAI in patients with DIS and NDIS. Results: The plasma PA activity of NDIS patients was higher than that of non-cerebral infarction patients on 4 ~ 21 days. The PA activity of DIS patients was lower than that of NDIS patients at 7h ~ 21d, but there was no significant difference in PAI activity between the two groups. CONCLUSION: The plasma PA activity in patients with DIS is lower than that in patients with NDIS, suggesting that there is disorder of activation of fibrinolytic system and may be related to the exacerbation of DIS.