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目的 研究心脏肌钙蛋白I(cTnI)对不稳定性心绞痛预后的影响。方法 用发光免疫方法测定30例不稳定性心绞痛(UA)患者入院即刻、第2、3日血浆cTnI水平,按cTnI≥0.1 ng/ml或<0.1 ng/ml将患者分为cTnI增高组和cTnI正常组;观察住院期间两组急性心肌梗死(AMI)心脏性死亡和难治性心绞痛的发生率。结果 30例UA患者中,cTnI增高10例(33％),cTnI正常20例(67％)。住院期间发生AMI 6例(20％),死亡2例(7％),难治性心绞痛5例(17％)。cTnI增高者AMI、非致死性心肌梗死及心脏性死亡的发生率显著高于cTnI正常者(P<0.01)。结论cTnI有助于评估UA的近期预后和指导治疗。
Objective To investigate the effect of cardiac troponin I (cTnI) on the prognosis of unstable angina pectoris. Methods The levels of cTnI in 30 patients with unstable angina pectoris (UA) immediately before admission and on day 2 and 3 were measured by luminescence immunoassay. The patients were divided into cTnI increasing group and cTnI group according to cTnI≥0.1 ng / ml or <0.1 ng / ml Normal group. The incidences of cardiac death and refractory angina were observed in two groups of acute myocardial infarction (AMI) during hospitalization. Results In 30 UA patients, cTnI increased in 10 (33%) and normal cTnI in 20 (67%) patients. AMI occurred during hospitalization in 6 cases (20%), death in 2 cases (7%), refractory angina in 5 cases (17%). The incidence of AMI, non-fatal myocardial infarction and cardiac death in patients with elevated cTnI was significantly higher than those with normal cTnI (P <0.01). Conclusions cTnI is useful in assessing the near-term prognosis and guiding treatment of UA.