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目的探讨儿童超重与代谢综合征(MS)的相关性。方法回顾性调查分析某院2002年1月～2011年12月期间在门诊就诊的肥胖儿及超重儿为研究对象,按照体重指数分组分为超重儿174例、肥胖儿154例。同时以同期住院治疗体重指数正常的仅仅患呼吸道疾病患儿325例为对照组。分析腰围、臀围、收缩压(SBP)、舒张压(DBP)、空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、空腹胰岛素(FINS)及计算胰岛素抵抗指数(HOMA-IR)。结果 (1)对照组MS患病率0.00%,超重儿MS患病率6.90%,肥胖儿MS患病率25.32%,随着体重指数的升高,MS患病率呈现升高趋势,三组MS患病率比较差异有统计学意义(χ~2=93.35,P﹤0.01)。(2)腰围、臀围、SBP、DBP、FBG、TC、TG、HDL-C、LDL-C、ALT、AST、FINS、HOMA-IR等检测指标结果在对照组、超重儿、肥胖儿中以逐渐升高趋势分布,并且超重儿与对照组、肥胖儿与对照组组间各指标比较差异均有统计学意义(P﹤0.05)。(3)BMI、腰围、SBP、TC、TG、LDL-C、ALT、AST、FINS与HOMA-IR呈正相关,HDL-C与HOMA-IR呈负相关(均P﹤0.01)。结论超重及肥胖儿童MS发病率明显较正常体重儿童升高,MS发病与超重及肥胖密切相关,应注重预防超重及肥胖。
Objective To investigate the correlation between overweight and metabolic syndrome (MS) in children. Methods Retrospective analysis of a hospital from January 2002 to December 2011 outpatient visits in obese children and overweight children as the research object, divided into body mass index according to 174 cases of overweight children, obese children in 154 cases. At the same time, only 325 children with respiratory diseases who had normal body mass index were hospitalized for the same period as the control group. The changes of waist circumference, hip circumference, SBP, DBP, FBG, TC, TG, HDL-C, LDL-C, ALT, AST, FINS and HOMA-IR were calculated. Results (1) The prevalence of MS in control group was 0.00%, the prevalence of MS in overweight children was 6.90% and the prevalence of MS in obese children was 25.32%. The prevalence of MS showed an increasing trend with the increase of body mass index. The prevalence of MS was significantly different (χ ~ 2 = 93.35, P <0.01). (2) The indexes of waist circumference, hip circumference, SBP, DBP, FBG, TC, TG, HDL-C, LDL-C, ALT, AST, FINS and HOMA-IR in control group, overweight children and obese children Gradually increased trend distribution, and there was significant difference between the overweight children and the control group, the obese children and the control group (P <0.05). (3) There was a positive correlation between BMI, waist circumference, SBP, TC, TG, LDL-C, ALT, AST, FINS and HOMA-IR. HDL-C was negatively correlated with HOMA-IR. Conclusion The incidence of MS in overweight and obese children is significantly higher than that of normal weight children. The incidence of MS is closely related to overweight and obesity, and prevention of overweight and obesity should be emphasized.