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目的探讨药物雾化吸入治疗小儿呼吸道感染的临床疗效及共对血清C-反应蛋白(CRP)、中性粒细胞、白细胞水平的影响。方法将204例呼吸道感染患儿随机分为试验组和对照组各102例。试验组给予盐酸氨溴索雾化吸入治疗,对照组给予盐酸氨溴索静脉注射治疗。2组患者均给予相同对症治疗,抗生素抗感染和营养支持,检测2组患者治疗前后CRP、中性粒细胞及白细胞水平,观察2组患者治疗效果,比较其差异。结果治疗前2组CRP、中性粒细胞和白细胞差异均无统计学意义(P>0.05)。治疗后2组CRP、中性粒细胞、白细胞水平均低于治疗前,且试验组低于对照组,差异均具有统计学意义(P>0.05)。试验组患者咳嗽消失时间、啰音消失时间和住院时间均短于对照组,差异均有统计学意义(P<0.05)。试验组患者治疗总有效率为91.18%远高于对照组的74.51%,差异有统计学意义(P<0.05)。结论药物雾化吸入治疗小儿呼吸道感染可显著降低患者血清CRP、中性粒细胞、白细胞水平,缩短患者治疗所需时间,提高治疗效果。
Objective To investigate the clinical efficacy of nebulized inhalation of drug in children with respiratory tract infection and the effects on the levels of serum C-reactive protein (CRP), neutrophils and leucocytes. Methods Totally 204 children with respiratory tract infection were randomly divided into experimental group and control group with 102 cases each. The experimental group was given inhalation of ambroxol hydrochloride inhalation, while the control group was given ambroxol hydrochloride intravenously. Both groups were given the same symptomatic treatment, anti-infectives and nutritional support of antibiotics. The levels of CRP, neutrophils and leucocytes in two groups were detected before and after treatment. The therapeutic effects were observed in two groups and compared. Results There were no significant differences in CRP, neutrophils and leukocytes between the two groups before treatment (P> 0.05). The levels of CRP, neutrophil and leucocyte in the two groups after treatment were all lower than those before treatment, and the difference between the two groups was statistically significant (P> 0.05). Cough disappear time, rales disappear time and hospital stay in trial group were shorter than those in control group, the difference was statistically significant (P <0.05). The total effective rate of treatment group was 91.18%, which was significantly higher than that of control group (74.51%) (P <0.05). Conclusion The inhalation of drugs in children with respiratory tract infections can significantly reduce the serum CRP, neutrophils, leukocytes, shorten the time required for treatment of patients and improve the therapeutic effect.