儿茶酚胺(CA)是交感神经活性递质,也是研究交感神经—肾上腺系统的一个重要指标。因此,许多学者研究寻找测定它的敏感而又特异的方法。而用放射免疫分析法(RIA)检测 CA 是众所注意的技术。但是 CA 本身易氧化,不易获得特异抗体。Grote 等报告 CA抗体的制备,但未能成功应用。随后 Lem等和 Raum 应用脱氧肾上腺素与蛋白偶联制备抗血清,建立了尿中变肾上腺素 RIA.随后 Raum 建立了 CA 的检测方法。本文应 Catecholamine (CA) is a neurotransmitter of sympathetic activity and an important indicator of the sympathetic-adrenal system. Therefore, many scholars study to find a sensitive and specific method of determining it. The detection of CA by radioimmunoassay (RIA) is a well-known technique. But CA itself easily oxidized, difficult to obtain specific antibodies. Grote et al. Reported the preparation of CA antibodies but failed to be used successfully. Subsequently, Lem et al. And Raum applied deoxyeptide and protein conjugation to prepare antisera and established urinary adrenergic RIA. Subsequently, Raum established a method for the detection of CA. This article should be