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【目的】探讨拟除虫菊酯农药暴露对婴儿生长发育的影响,为预防儿童农药中毒提供科学依据。【方法】选取江苏某县1岁婴儿449名,收集随机尿样检测拟除虫菊酯代谢物顺式-3-(2,2-二氯乙烯基)-2,2-二甲基环丙烷-1-羧酸(cis-Cl2CA)、反式-3-(2,2-二氯乙烯基)-2,2-二甲基环丙烷-1-羧酸(trans-Cl2CA)和3-苯氧基苯甲酸(3-PBA)水平,测量婴儿身长、体重、头围、胸围,用“0～6岁儿童发育筛查测验”(DST)评估婴儿智能发育状况,分析两者之间关系。【结果】研究对象尿样拟除虫菊酯代谢物cis-Cl2CA、trans-Cl2CA和3-PBA检出率分别为70.4%、97.6%和84.2%。按照总拟除虫菊酯浓度P25、P75分为低中高三组,不同暴露水平组之间婴儿的体重、胸围不完全相同,具有统计学意义(P<0.05),但身长、头围和发育商差异无统计学意义。多重线性回归分析亦提示尿拟除虫菊酯的浓度与体重有相关性(P<0.05)。【结论】拟除虫菊酯暴露对婴儿体重有一定的影响。
【Objective】 To investigate the effects of pyrethroid pesticide exposure on infant growth and development and provide a scientific basis for prevention of childhood pesticide poisoning. 【Method】 A total of 449 infants aged 1 year were selected from a county of Jiangsu Province. Random urine samples were collected for the determination of pyruvate metabolites cis-3- (2,2-dichlorovinyl) -2,2-dimethylcyclopropane-1 (Cis-Cl2CA), trans-3- (2,2-dichlorovinyl) -2,2-dimethylcyclopropane- 1-carboxylic acid (trans-Cl2CA) (3-PBA) was measured to measure the height, weight, head circumference and chest circumference of infants. The intelligence development status of infants was evaluated with the “Developmental Screening Test of Children 0-6 Years Old” (DST), and the relationship between them was analyzed. 【Results】 The detection rates of cis-Cl2CA, trans-Cl2CA and 3-PBA in the urine samples were 70.4%, 97.6% and 84.2%, respectively. According to the total pyrethroid concentration of P25, P75 is divided into low, medium and high groups, the body weight and chest circumference of different exposure groups are not completely the same, with statistical significance (P <0.05), but the differences of body length, head circumference and development quotient No statistical significance. Multiple linear regression analysis also suggested that there was a correlation between urinary pyrethroid concentration and body weight (P <0.05). 【Conclusion】 The pyrethroid exposure has a certain effect on the infant’s body weight.