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目的以西地兰为对照，观察干蟾皮水溶性提取物华蟾素对麻醉犬血流动力学的影响。方法健康杂种犬，戊巴比妥钠腹腔注射麻醉，插管测取心率（ＨＲ）、平均动脉压（ＭＡＰ）、左室收缩压（ＬＶＳＰ）、每分输出量（ＣＯ）、每搏输出量（ＳＶ），静推华蟾素或西地兰，分别观察用药前后血流动力学的变化。结果静推大剂量华蟾素（１ｇ／ｋｇ）后，麻醉犬的ＨＲ较用药前明显降低（Ｐ＜０．０５），ＭＡＰ、ＬＶＳＰ、ＣＯ轻度增加（Ｐ＞０．０５），ＳＶ明显增加（Ｐ＜０．０５）。与西地兰组比较，两组间ＨＲ降低无明显差异（Ｐ＞０．０５），用药后３０ｍｉｎ两组间ＣＯ和ＳＶ增加无明显差异（Ｐ＞０．０５），但６０ｍｉｎ时差异显著（Ｐ＜０．０１）。结论华蟾素对麻醉犬正常心脏有类似于洋地黄类药物的负性变时作用和较弱的正性变力作用。
Objective To observe the effects of cinobufacini on the hemodynamics of anesthetized dogs with cedilanid as control. Methods Healthy mongrel dogs were anesthetized by intraperitoneal injection of sodium pentobarbital, heart rate (HR), mean arterial pressure (MAP), left ventricular systolic pressure (LVSP), output per minute (SV), cinobufotalin or cedilamine, respectively, to observe the changes of hemodynamics before and after treatment. Results The HR of anesthetized dogs was significantly decreased (P <0.05), MAP, LVSP and CO slightly increased (P> 0.05) Increase (P <0.05). Compared with cedilanid group, there was no significant difference in HR between the two groups (P> 0.05). There was no significant difference in the increase of CO and SV between the two groups at 30 minutes after treatment (P> 0.05) P <0.01). CONCLUSION: Cinobufacini has a negative effect on the normal heart of anesthetized dogs, which is similar to that of digitalis, and a weak positive force.