H因子为补体第二前端反应序列中一个重要的负性调节蛋白,在防止补体第二途径的启动、沉积、识别与放大作用中具有重要性。它是一个分子量为155kD的单链糖蛋白,具有不同的构象形式,伸展时长495横径由1 213位氨基酸组成20个Sushi单位。H因子的基因位于1q 32,属于RCA基因族成员,但有H-相关基因的报道。H因子具有遗传多态性,至今已报道了5个别型。可能还有H因子受体存在于B淋巴细胞、单核巨噬细胞等处。 Factor H is an important negative regulatory protein in the second front-end reaction sequence of complement, which plays an important role in preventing the initiation, deposition, recognition and amplification of the second pathway of complement. It is a single-chain glycoprotein with a molecular weight of 155 kD, which has a different conformational form. Stretching time length 495 is composed of 20 Sushi units consisting of amino acids 1 to 213. The H factor gene is located at 1q32 and belongs to the RCA gene family but has H-related genes. H factor has genetic polymorphism, has been reported in 5 individual types. There may be H factor receptors present in B lymphocytes, monocytes and other macrophages.