肿瘤转移一直是肿瘤基础研究和临床治疗的热点和难点,肿瘤经淋巴道转移是否及如何依赖于淋巴管生成还存在争议,诸如肿瘤组织内是否存在淋巴管、肿瘤细胞如何进入淋巴管系统及经淋巴管转移的具体机制等尚未明确。最近,淋巴管特异性标志物D 2-40的发现和应用无疑为研究肿瘤相关淋 Tumor metastasis has always been a hot and difficult issue in basic research and clinical treatment of tumors. It is still controversial whether and how lymphatic metastasis depends on lymphangiogenesis, such as whether there are lymphatic vessels in tumor tissues, how tumor cells enter the lymphatic system, and The specific mechanism of lymphatic metastasis is not yet clear. Recently, the discovery and application of the lymphatic vessel-specific marker D 2-40 is undoubtedly to study tumor-related