骨折愈合是创伤愈合的一种特殊类型,其过程复杂,受多种因素影响,有着复杂的生物学机制。临床上观察到骨折合并脑外伤患者骨痂过度生长,甚至在肌肉中出现异位骨化,其骨折愈合速度明显加快[1]。虽然临床和实验研究都支持脑外伤促进骨折愈合的结论,但其发生机制尚未清楚。脑外伤合 Fracture healing is a special type of wound healing, the process is complex, affected by many factors, has a complex biological mechanism. Clinically observed in patients with traumatic brain injury bone callus overgrowth, and even heterotopic ossification in the muscle, the fracture healing rate was significantly accelerated [1]. Although both clinical and experimental studies support the conclusion that traumatic brain injury promotes fracture healing, the mechanism is still unclear. Traumatic brain injury