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目的:探讨白细胞介素-1琢(IL-1琢)是否参与髓核突出所致的坐骨神经疼痛的产生。方法:将大鼠自体尾椎的髓核无压迫下放置在L4和L5神经根表面,在术后不同时间测量大鼠后足对机械刺激敏感性的变化,同时用免疫组化方法对移植髓核中的IL-1琢进行检测。结果:在无明显机械压迫的情况下,大鼠腰神经根上放置自体髓核后,术侧后足可产生明显机械刺激痛觉过敏;实验组大鼠移植髓核组织中IL-1琢免疫组织化学染色阳性。结论:髓核组织的生物学作用是引起腰腿痛的重要因素,炎性介质IL-1琢可能参与疼痛的发生。
Objective: To investigate whether interleukin-1 (IL-1) is involved in the development of sciatic nerve pain caused by nucleus pulposus. METHODS: The nucleus pulposus of autologous caudal vertebrae was placed on the surface of L4 and L5 nerve roots without any compression. The sensitivity of rat hindpaw to mechanical stimulation was measured at different time points after operation. Meanwhile, The IL-1 in the nucleus is detected. Results: In the absence of significant mechanical compression, the autologous nucleus pulposus was placed on the lumbar nerve root of rats, and the posterior hindpaw could produce obvious mechanical stimulation of hyperalgesia. In the experimental group, the expression of IL-1 in the nucleus pulposus of the rats Positive staining. Conclusion: The biological effect of nucleus pulposus is an important factor of low back pain. Inflammatory mediator IL-1 may participate in the occurrence of pain.