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局部复发是直肠癌术后的主要并发症.文献报道:5-Fu栓剂能使肿瘤缩小和细胞退行性变,兼有杀死细胞和使肿瘤细胞对放疗敏感.栓剂能在直肠内及局部淋巴结内产生显著高于全身用药的浓度.本实验试图将5-Fu栓剂和照射结合应用以达到预防术后局部复发的目的.材料和方法:第一批93例直肠癌患者,其中53例(栓剂组)直肠内给5-Fu栓剂,200mg每日二次,用10～30天.另40例不给术前治疗而直接手术.第二批72例,X片上显示肿块>5cm,无淋巴结外任何转移证
Local recurrence is a major complication of rectal cancer surgery. It is reported in the literature that 5-Fu suppository can shrink tumors and degenerate cells, kill both cells and make tumor cells sensitive to radiotherapy. Suppository can be in the rectum and local lymph nodes. The intrinsically-produced concentration was significantly higher than that of systemic administration. This experiment attempted to combine 5-Fu suppository with irradiation to achieve the goal of preventing postoperative local recurrence. Materials and Methods: The first 93 patients with rectal cancer, of which 53 (suppository Group) intrarectal 5-Fu suppository, 200mg twice daily, with 10 to 30 days. The other 40 cases without direct surgery and direct surgery. The second group of 72 cases, X-chip showed mass> 5cm, no lymph nodes outside Any transfer card