1临床资料患者男,45岁,因皮肤多发性结节于2010年7月4日来我科就诊。患者自幼年发病,胸背部皮肤出现多处深棕色斑片,13岁左右开始皮肤出现大小不等的半球形结节,随年龄增长逐渐增多,无痒痛及不适感。背部较大瘤体曾手术切除治疗。患者平素体健,智力正常,一级亲属中母亲、姐姐及儿子发病。父母非近亲结婚。体格检查:一般状况良好,各系统检查未见异常。皮肤科检查:躯干部皮肤散布数百个半球形 1 Clinical data Male patient, 45 years old, due to skin multiple nodules in July 4, 2010 to our department. Patients from the onset of childhood, chest and back skin showed multiple dark brown patches, 13-year-old began to appear on the skin hemispherical nodules of varying sizes, with increasing age gradually increased, no itch and discomfort. The back of the larger tumor surgery has been removed. Patients usually physical health, mental normal, first-degree relatives in the mother, sister and son of the disease. Parents marry non-relatives. Physical examination: the general condition is good, the system check no abnormalities. Dermatological examination: the trunk of the skin is distributed hundreds of hemispheres