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目的:观察分析糖尿病肾病合并高血压患者采用坎地沙坦与贝那普利联合治疗的临床疗效。方法:选取该院2014年3月至2015年9月收治的82例糖尿病肾病合并高血压患者按照随机抽签法分为研究组(采用坎地沙坦与贝那普利联合治疗)和对照组(单独采用坎地沙坦治疗),对比分析两组患者治疗前后舒张压(DBP)、收缩压(SBP)、血清肌酐(Scr)、24 h尿蛋白、尿素氮(BUN)、血钾等指标水平变化情况。结果:两组患者治疗后DBP、SBP水平相对于治疗前均有所降低(P<0.05),而且研究组患者治疗后DBP、SBP水平均明显低于对照组(P<0.05)。结论:糖尿病肾病合并高血压患者采用坎地沙坦与贝那普利联合治疗的临床效果良好,可有效降低患者血压以及尿蛋白水平,帮助患者改善肾脏功能,值得在临床上广泛推广、应用。
Objective: To observe and analyze the clinical efficacy of combination therapy of candesartan and benazepril in patients with diabetic nephropathy complicated with hypertension. Methods: Eighty-two patients with diabetic nephropathy complicated with hypertension admitted to our hospital from March 2014 to September 2015 were randomly divided into study group (combination of candesartan and benazepril) and control group (Treated with candesartan alone). The levels of DBP, SBP, Scr, 24h urinary protein, BUN and K were compared between the two groups before and after treatment. Changes. Results: The levels of DBP and SBP in both groups after treatment were lower than those before treatment (P <0.05), and the levels of DBP and SBP in the study group were significantly lower than those in the control group (P <0.05). Conclusion: The combination of candesartan and benazepril in patients with diabetic nephropathy complicated with hypertension has a good clinical effect, which can effectively reduce the blood pressure and urinary protein level in patients with kidney disease and help patients to improve renal function. It is worth widely used in clinic.