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目的:观察益气养阴通络方对2型糖尿病大鼠骨骼肌、脂肪组织GLUT4蛋白表达的影响。方法:高脂饲料喂养,一次性尾静脉注射STZ30mg/kg造模,益气养阴通络方治疗。放射免疫分析法检测血清FINS,免疫荧光法检测骨骼肌、脂肪组织GLUT4蛋白表达。结果:益气养阴通络方可增加2型糖尿病大鼠骨骼肌、脂肪组织GLUT4蛋白表达。结论:益气养阴通络方降低血糖,改善IR的机理可能与其增加2型糖尿病大鼠骨骼肌、脂肪组织GLUT4蛋白表达有关。
Objective: To observe the effect of Yiqi Yangyin Tongluo Fang on GLUT4 protein expression in skeletal muscle and adipose tissue of type 2 diabetic rats. Methods: High-fat diet feeding, one-time tail vein injection of STZ 30mg/kg model, Yiqi Yangyin Tongluo treatment. Serum FINS was detected by radioimmunoassay and GLUT4 protein expression in skeletal muscle and adipose tissue was detected by immunofluorescence. Results: Yiqi Yangyin Tongluo Prescription can increase GLUT4 protein expression in skeletal muscle and adipose tissue of type 2 diabetic rats. Conclusion: The mechanism of reducing blood glucose and improving IR by Yiqi Yangyin Tongluo Fang may be related to the increase of GLUT4 protein expression in skeletal muscle and adipose tissue of type 2 diabetic rats.