Dexmedetomidine and its novel salt have been synthesized and characterized by single-crystal XRD and TGA/DSG.Components of the crystalline phase have also been investigated in terms of their corresponding Hirshfeld surface.In the crystal lattice,a three-dimensional hydrogen-bonded network is observed.In this work,the salt strategy has been applied successfully to dexmedetomidine.One important parameter,i.e.stability,has also been significantly improved,which proves to be an important factor for solid dosage formulation.Furthermore,DSC/TGA analysis indicates that the salt maintains its crystallinity up to 300 ℃,suggesting a higher stability of the salt compared to pure dexmedetomidine. Dexmedetomidine and its novel salt have been synthesized and characterized by single-crystal XRD and TGA / DSG. Components of the crystalline phase have also been investigated in terms of their corresponding Hirshfeld surface. In the crystal lattice, a three-dimensional hydrogen-bonded network is observed. this work, the salt strategy has been applied successfully to dexmedetomidine. One important parameter, ie stability, has also significantly significantly improved, which proves to be an important factor for solid dosage formulation. Morerther, DSC / TGA analysis indicates that the salt maintains its crystallinity up to 300 ° C suggesting a higher stability of the salt compared to pure dexmedetomidine.