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目的:观察稳消II方对动脉粥样硬化模型兔脂质代谢的影响,探讨其防治动脉粥样硬化的作用机制。方法:将38只健康新西兰大白兔随机分为空白组9只和造模组29只。空白组予标准饲料,造模组予高脂饲料喂养8周,第8周末随机处死2只。造模成功后随机分为稳消II方干预组(9只)、辛伐他汀对照组(9只)、模型对照组(9只),并改用标准饲料喂养。分别予相应药物灌胃干预8周[模型对照组与空白对照组均予生理盐水10 m L/(kg·d)]。分别于第0、8、16周末进行耳缘静脉采血,检测TC、TG、HDL-C、LDL-C、ALT、AST、Cr、BUN、UA、CK水平。结果:稳消II方干预组、辛伐他汀对照组TC、TG、LDL-C水平均低于模型对照组,HDL-C水平高于模型对照组,差异均有统计学意义(P<0.05)。稳消II方干预组、辛伐他汀对照组与空白对照组比较,TC、TG水平差异均无统计学意义(P>0.05);稳消II方干预组、辛伐他汀对照组LDL-C、HDL-C水平高于空白对照组,差异有统计学意义(P<0.05)。稳消II方干预组与辛伐他汀对照组比较,TC、TG、LDL-C、HDL-C水平差异均无统计学意义(P>0.05)。稳消II方组、辛伐他汀组干预前后自身对照比较,TC、LDL-C、TG水平均显著下降,HDL-C水平明显上升,差异均有统计学意义(P<0.05)。结论:稳消II方可降低动脉粥样硬化兔TC、TG、LDL-C,升高HDL-C水平,调节脂质代谢,改善和延缓动脉粥样硬化,且其对实验兔ALT、AST、Cr、BUN、UA、CK无不良影响。
Objective: To observe the effects of Wenxiao II on lipid metabolism in atherosclerotic rabbits and to explore the mechanism of prevention and treatment of atherosclerosis. Methods: Thirty-eight healthy New Zealand white rabbits were randomly divided into blank group (n = 9) and model group (n = 29). The blank group was given standard feed, while the model group was fed with high fat diet for 8 weeks. Two rabbits were randomly sacrificed at the end of the 8th week. The rats were randomly divided into two groups (n = 9), simvastatin control group (n = 9) and model control group (n = 9). Respectively, the corresponding drug gavage intervention for 8 weeks [model control group and blank control group were given normal saline 10 m L / (kg · d)]. Blood samples were taken from the ear vein on the 0th, 8th and 16th week respectively to detect the levels of TC, TG, HDL-C, LDL-C, ALT, AST, Cr, BUN, UA and CK. Results: The levels of TC, TG and LDL-C in steady-cancerous II-intervention group and simvastatin control group were lower than those in model control group, and the levels of HDL-C were higher than those in model control group (P <0.05) . There were no significant differences in TC and TG levels between the two groups (P <0.05), the steady-state II intervention group and the simvastatin control group compared with the blank control group (P> 0.05) HDL-C levels higher than the blank control group, the difference was statistically significant (P <0.05). There was no significant difference in the levels of TC, TG, LDL-C and HDL-C between the two groups (P <0.05). The levels of TC, LDL-C and TG were significantly decreased, and the level of HDL-C was significantly increased (P <0.05). Conclusion: Stabilization II can reduce atherosclerosis rabbits TC, TG, LDL-C, increase HDL-C levels, regulate lipid metabolism, improve and delay atherosclerosis, and its effects on ALT, AST, Cr, BUN, UA, CK no adverse effects.