系统性红斑狼疮、特别是狼疮性肾炎患者经常合并各种动、静脉血栓,其发生机制主要与免疫炎症激活内、外源性凝血途径和损伤内皮细胞有关;抗凝治疗可以阻断炎症与凝血间的正性循环,从而不仅可以防治血栓栓塞性疾病,而且可以减轻狼疮性肾炎的肾脏组织炎症反应,减轻肾脏损害。 Systemic lupus erythematosus, especially patients with lupus nephritis often combined with a variety of arterial and venous thrombosis, its mechanism of occurrence and immune inflammation mainly activated, extrinsic coagulation pathway and damage to endothelial cells; anticoagulant therapy can block inflammation and coagulation Between the positive cycle, which can not only prevent thromboembolic diseases, but also can reduce the lupus nephritis renal tissue inflammatory response and reduce renal damage.