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为探讨肺炎患儿感染柯萨奇病毒（CVB）后对机体免疫功能的影响，与细胞因子在小儿肺炎发生发展中的作用，检测了45例肺炎患儿的CVB-IgM、白细胞介素-2（IL－2）及可溶性IL-2受体（sIL-2R）。肺炎患儿IL－2水平显著低于正常组，sIL－2R水平显著高于正常组。喘憋组CVB－IgM阳性率及sIL－2R水平显著高于非瑞憋组，IL－2水平显著低于非喘憋组；而CVB－IgM阳性者与CVB－IgM阴性者之间，IL－2及sIL－2R水平无显著不同。结果提示，IL－2及sIL－2R在肺炎的发生发展过程中起重要作用，IL－2及sIL－2R水平变化似与CVB感染无密切关系。
To investigate the effect of Coxsackie virus (CVB) infection on immune function in children with pneumonia and the role of cytokines in the development of pneumonia in children, the levels of CVB-IgM, interleukin-2 (IL-2) and soluble IL-2 receptor (sIL-2R). The level of IL-2 in children with pneumonia was significantly lower than that in the normal group, and the level of sIL-2R in children with pneumonia was significantly higher than that in the normal group. The positive rate of CVB-IgM and the level of sIL-2R in asthmatic group were significantly higher than those in non-rehosinate group, while the levels of IL-2 in CVB-IgM were significantly lower than those in non-asthmatic group. However, 2 and sIL-2R levels were not significantly different. The results suggest that IL-2 and sIL-2R plays an important role in the pathogenesis of pneumonia. The changes of IL-2 and sIL-2R may not be closely related to CVB infection.