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作者观察了通过慢性套管向家兔侧脑室、中脑导水管周围灰质和小脑延髓池注射吗啡后血糖浓度的变化。结果如下:(1)向双侧侧脑室注射吗啡引起血糖浓度明显升高,这一高血糖效应呈剂量—反应关系;由静脉注入相同剂量的吗啡不影响血糖水平。(2)吗啡的高血糖效应可由预先注入侧脑室的鸦片受体阻断剂纳洛酮所阻断。(3)吗啡注入小脑延髓池引起的高血糖反应较注入侧脑室为快。(4)吗啡注入中脑导水管周围灰质可特异性地引起血糖升高。(5)切除双侧内脏大神经可消除吗啡的高血糖效应。(6)静脉输入吗啡可引起急性吗啡耐受,一旦产生吗啡耐受,吗啡的高血糖效应便不再出现。
The authors observed changes in blood glucose levels after morphine injection into the lateral ventricle of the rabbit, periaqueductal gray and the cisterna magna through chronic cannulas. The results are as follows: (1) Intracerebroventricular injection of morphine caused a significant increase in blood glucose levels, the hyperglycemic effect was dose-response relationship; intravenous injection of the same dose of morphine did not affect blood glucose levels. (2) Morphine hyperglycemia can be blocked by naloxone, an opioid receptor blocker pre-infused into the lateral ventricle. (3) morphine injected into the cerebellar cistern caused by hyperglycemic response into the lateral ventricle faster. (4) morphine injected into the midbrain periaqueductal gray matter can specifically cause elevated blood sugar. (5) The removal of bilateral visceral nerve can eliminate the high blood sugar effect of morphine. (6) Intravenous morphine can cause acute morphine tolerance. Once morphine tolerance occurs, the hyperglycemic effect of morphine disappears.