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HIC-1(hypermethylated in cancer 1)基因定位于染色体17p13.3位点、肿瘤抑制基因p53远端,能编码一种转录抑制因子,该转录抑制因子识别的靶基因与细胞增殖、肿瘤生长、血管生成及侵犯等作用有关。研究表明,HIC-1基因的甲基化与乳腺癌的发生过程相关,且乳腺癌细胞中HIC-1表达缺失与p53的失活有协同作用。目前,应用甲基化酶抑制剂等恢复HIC-1基因的活性,作为治疗肿瘤的策略引起人们的广泛关注,对其作用机制以及调控分子网络的深入探讨将为肿瘤的治疗提供新的途径。
HIC-1 (hypermethylated in cancer 1) gene locates on chromosome 17p13.3 and is distal to tumor suppressor gene p53, which encodes a transcriptional repressor. The target genes identified by this transcriptional repressor are associated with cell proliferation, tumor growth, Generated and violations such as the role. Studies have shown that HIC-1 gene methylation is associated with the development of breast cancer, and the lack of expression of HIC-1 in breast cancer cells has a synergistic effect with p53 inactivation. At present, the application of methylase inhibitors and the like to restore the activity of HIC-1 gene has drawn much attention as a strategy for the treatment of tumors, and further discussion on its mechanism of action and regulation of molecular networks will provide a new approach for the treatment of tumors.